Our lab studies environmentally-switched protein/protein interaction domains about their natural regulation and understand how to artificially control them in vitro and in living cells. This is exemplified by our work on photosensors, parts of the hypoxia response, and others.

April 2016: Welcome to new lab members Zaynab Jaber and Uthama Edupuganti, joining us at the Structural Biology Initiative of the CUNY Advanced Science Research Center. Kevin directs this new initiative, which will catalyze collaborations among biological and physical scientists in the ASRC and elsewhere in the CUNY system.

Please find me by email with any questions or comments - Kevin Gardner kglab.org

for April 25, 2017, as found in TD McKee et al., Biochemistry 46(2007): 12248:

"We interpret our results according to a model in which the mutation and 11-cis retinal acts as a 'steric doorstop' forcing the protein into a more open and active conformation that is dependent on the larger group at 118 and the 9-methyl group of retinal."