New Ph.D. students: Welcome to Zaynab Jaber and Uthama Edupuganti, Ph.D. students in the CUNY Biochemistry Ph.D. program, who've joined the lab in spring 2016!

Just out - photoreceptors: We've examined the generality of the signaling model we determined for the phototropin/AsLOV2 system (Harper et al. 2003). An analogous mechanism is used is by EL222, a LOV-HTH protein (Nash et al. 2011, Rivera-Cancel et al. 2012), and EL346, a LOV-HK kinase (Corrêa et al., 2013, Rivera-Cancel et al. 2014), to convert light into changes in DNA binding and enzymatic activities. We've taken advantage of this to develop new optogenetic tools (Motta-Mena et al. 2014), and think that similar strategies can be applied to other LOV proteins (Glantz et al. 2016).

Just out - bHLH/PAS: We've reported two small molecule approaches to inhibit the HIF transcription factors in living cells. One route exploits a large cavity within the HIF-2α PAS-B domain (Scheuermann et al. 2009, Key et al. 2009), providing a site for high-affinity ligands to trigger allosteric changes that disrupt HIF-2α/ARNT complexes (Scheuermann et al. 2013, Scheuermann et al. 2015). Another strategy targets all HIF isoforms (Guo et al. 2013, Guo et al. 2015) by disrupting interactions between the ARNT subunit and CCC coactivator proteins, including TACC3 (Partch and Gardner 2011).

for September 21, 2019, as found in J Kuriyan, Cell 116(2004): 356:

"In our quest to understand how proteins work, things would be much easier if protein domains were rigid and simply did whatever it is that they are supposed to do without jiggling around too much."